Understanding the Value of Backbone Organizations in Collective Impact

Effective backbone support is a critical condition for collective impact. In fact, it is the number one reason that collective impact initiatives fail. In this publication, we provide communities and organizations engaged in collective impact with guidance on the role of the backbone and how to understand and support its effectiveness.In the Greater Cincinnati region, collective impact has become the "new normal," and The Greater Cincinnati Foundation (GCF) has made a commitment to support the infrastructure of collective impact - the backbone organization itself - in an effort to sustain and scale long-term systemic change and impact in the community. However, the role of the backbone organization in collective impact is complex and can be difficult to explain.In early 2012, The Greater Cincinnati Foundation and FSG began a partnership to define the value of backbone organizations and better understand back-bone effectiveness by working with six local backbone organizations and collective impact initiatives

The contour tree image encoding technique and file format

The process of contourization is presented which converts a raster image into a discrete set of plateaux or contours. These contours can be grouped into a hierarchical structure, defining total spatial inclusion, called a contour tree. A contour coder has been developed which fully describes these contours in a compact and efficient manner and is the basis for an image compression method. Simplification of the contour tree has been undertaken by merging contour tree nodes thus lowering the contour tree's entropy. This can be exploited by the contour coder to increase the image compression ratio. By applying general and simple rules derived from physiological experiments on the human vision system, lossy image compression can be achieved which minimises noticeable artifacts in the simplified image. The contour merging technique offers a complementary lossy compression system to the QDCT (Quantised Discrete Cosine Transform). The artifacts introduced by the two methods are very different; QDCT produces a general blurring and adds extra highlights in the form of overshoots, whereas contour merging sharpens edges, reduces highlights and introduces a degree of false contouring. A format based on the contourization technique which caters for most image types is defined, called the contour tree image format. Image operations directly on this compressed format have been studied which for certain manipulations can offer significant operational speed increases over using a standard raster image format. A couple of examples of operations specific to the contour tree format are presented showing some of the features of the new format.Science and Engineering Research Counci

Call-by-name, Call-by-value, Call-by-need, and the Linear Lambda Calculus

Girard described two translations of intuitionistic logic into linear logic, one where A -> B maps to (!A) -o B, and another where it maps to !(A -o B). We detail the action of these translations on terms, and show that the first corresponds to a call-by-name calculus, while the second corresponds to call-by-value. We further show that if the target of the translation is taken to be an affine calculus, where ! controls contraction but weakening is allowed everywhere, then the second translation corresponds to a call-by-need calculus, as recently defined by Ariola, Felleisen, Maraist, Odersky, and Wadler. Thus the different calling mechanisms can be explained in terms of logical translations, bringing them into the scope of the Curry-Howard isomorphism

New crystal packing arrangements in radical cation salts of BEDT-TTF with [Cr(NCS)6]3− and [Cr(NCS)5(NH3)]2−

BEDT-TTF forms three packing arrangement styles in its radical cation salts with [Cr(NCS)6]3− in two of which two trans-oriented isothiocyanate ligands penetrate the BEDT-TTF layers either at the point where a solvent (nitrobenzene) is incorporated in a stack of donors or by four donor molecules forming a “tube” motif to accept a ligand at each end along with a small solvent molecule in between (acetonitrile). The [Cr(NCS)5NH3]2− ion forms a related crystal packing arrangement with BEDT-TTF with a reduction in the number of “tube” motifs needed to accept an isothiocyanate ligand

Intellectual Property Law and Entertainment Law Issues

The University of Georgia School of Law\u27s Dean Rusk Center hosted an intellectual property law lecture featuring Martin Kretschmer, professor of information jurisprudence and director of the Centre for Intellectual Property Policy & Management at Bournemouth University, U.K. Kretschmer discussed his groundbreaking work in artist compensation in the European Union as well as the contractual structures that drive creative industries on April 6 at 1:30 p.m. in the Larry Walker Room of Dean Rusk Hall. His lecture was followed by comments from W. Bruce Burch, UGA director of Interdisciplinary Certificate in Music Business; Bertis E. Downs IV, Georgia Law adjunct professor and general counsel for the music group R.E.M.; and John L. Turner, UGA Terry College of Business associate professor

Fur removal promotes an earlier expression of involution-related genes in mammary gland of lactating mice

Open Access via the Springer Compact Agreement We greatly benefited from discussing our work with Drs Torsten Stein, Wendy Woodward (who shared her raw data with us), and Sally Ward. We thank Catherine Hambly and Peter Thomson for assistance with isotope analyses. Acknowledgements We greatly benefited from discussing our work with Drs Torsten Stein, Wendy Woodward (who shared her raw data with us), and Sally Ward. We thank Catherine Hambly and Peter Thomson for assistance with isotope analyses. Funding The study was funded by Biotechnology and Biological Sciences Research Council (BBSRC) grants BB/G009953/1, BB/P009875/1 and BB/J020029/1, awarded to JRS. EK was supported by BBSRC grants BB/C504794/1 and BB/R018812/1.Peer reviewedPublisher PD

Framing policy on low emissions vehicles in terms of economic gains: Might the most straightforward gain be delivered by supply chain activity to support refuelling?

The work reported here is a result of the EPSRC Hydrogen and Fuel Cell Research Hub research programme (Grant ref. EP/J016454/1). A core theme of the UK Government's new Industrial Strategy is exploiting opportunities for domestic supply chain development. This extends to a special Automotive Sector Deal that focuses on the shift to low emissions vehicles (LEVs). Here attention is on electric vehicle and battery production and innovation. In this paper, we argue that a more straightforward gain in terms of framing policy around potential economic benefits may be made through supply chain activity to support refuelling of battery/hydrogen vehicles. We set this in the context of LEV refuelling supply chains potentially replicating the strength of domestic upstream linkages observed in the UK electricity and/or gas industries. We use input-output multiplier analysis to deconstruct and assess the structure of these supply chains relative to that of more import-intensive petrol and diesel supply. A crucial multiplier result is that for every £1million of spending on electricity (or gas), 8 full-time equivalent jobs are supported throughout the UK. This compares to less than 3 in the case of petrol/diesel supply. Moreover, the importance of service industries becomes apparent, with 67% of indirect and induced supply chain employment to support electricity generation being located in services industries. The comparable figure for GDP is 42%. Publisher PDF Peer reviewed Document type: Boo

Screening asymptomatic men for prostate cancer::a comparison of international guidelines on prostate-specific antigen testing

OBJECTIVE: To summarise and compare the key recommendations on prostate-specific antigen (PSA)-based screening for prostate cancer, and so highlight where more evidence is required to facilitate consistent recommendations. METHODS: The Medline database and websites of 18 national screening organisations and professional associations were searched between January 2010 and November 2020 to identify screening guidelines published in English, considering recent clinical trials. RESULTS: Population-based PSA testing of asymptomatic men is not widely recommended. Guidelines emphasize shared patient-clinician decision making. For ‘average-risk’ men choosing to be screened, the recommended age varies from 50–55 to 70 years, alongside consideration of life expectancy (ranging from 7–15 years). Screening intervals, when specified, are biennial (most common), annual, or determined from baseline PSA. The earliest age for screening high-risk men (frequently defined as of African descent or with a family history of prostate cancer) is 40 years, but recommendations often defer to clinical judgement. CONCLUSIONS: Population screening of asymptomatic men is not widely recommended. Instead, balancing the potential harms and benefits of PSA testing is endorsed. Variation between guidelines stems from differing interpretations of key trials and could lead to clinician-dependent screening views. The development of clinical decision aids and international consensus on guidelines may help reduce national and international variation on how men are counselled

Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non–Small Cell Lung Cancer: A Phase Ib Study

Purpose: Abemaciclib, a dual inhibitor of cyclin-dependent kinases 4 and 6, has demonstrated preclinical activity in non–small cell lung cancer (NSCLC). A multicenter, nonrandomized, open-label phase Ib study was conducted to test safety, MTD, pharmacokinetics, and preliminary antitumor activity of abemaciclib in combination with other therapies for treatment in patients with metastatic NSCLC. Patients and Methods: An initial dose escalation phase was used to determine the MTD of twice-daily oral abemaciclib (150, 200 mg) plus pemetrexed, gemcitabine, or ramucirumab, followed by an expansion phase for each drug combination. Pemetrexed and gemcitabine were administered according to label. The abemaciclib plus ramucirumab study examined two dosing schedules. Results: The three study parts enrolled 86 patients; all received ≥1 dose of combination therapy. Across arms, the most common treatment-emergent adverse events were fatigue, diarrhea, neutropenia, decreased appetite, and nausea. The trial did not identify an abemaciclib MTD for the combination with pemetrexed or gemcitabine but did so for the combination of abemaciclib with days 1 and 8 ramucirumab (8 mg/kg). Plasma sample analysis showed that abemaciclib did not influence the pharmacokinetics of the combination agents and the combination agents did not affect abemaciclib exposure. The disease control rate was 57% for patients treated with abemaciclib–pemetrexed, 25% for abemaciclib–gemcitabine, and 54% for abemaciclib–ramucirumab. Median progression-free survival was 5.55, 1.58, and 4.83 months, respectively. Conclusions: Abemaciclib demonstrated an acceptable safety profile when dosed on a continuous twice-daily schedule in combination with pemetrexed, gemcitabine, or ramucirumab. Abemaciclib exposures remained consistent with those observed in single-agent studies